NIH R01 · 2024
Corticolimbic Circuits in Negative Affect
Project Summary/Abstract The ability to seek out situations that elicit pleasure and avoid those that lead to aversion or discomfort is a fundamental ability we all share, yet dysfunctional hedonic processing is prevalent in numerous psychiatric illnesses including substance use disorders (SUDs), alcohol abuse, and depression. As such, it is critical to understand the basic neural mechanisms underlying aversive affective states to ultimately apply treatment strategies to restore normal hedonic processing and aid in the recovery of maladaptive behaviors in mental illness. Here, we seek to understand the role of ‘top-down’ medial prefrontal cortex (mPFC) to nucleus accumbens (NAc) processing…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.