NIH R01 · 2024
Inflammation Phenotypes in Pediatric Sepsis Induced Multiple Organ Failure Renewal
Project Abstract Every year over 1 million American adults and children develop overwhelming infection leading to a rotting of their body we call ‘sepsis’, and death in up to 1 of 4 afflicted. We and others have asked the question “why do patients continue to die of organ shutdown?” In the previous funding period we used clinical information and samples already obtained in our R01 funded audit of 401 children with sepsis and took advantage of the wonderful advances made this millenia in computer technology, big data, bioinformatics, and the study of human and virus genetics to understand how too much inflammation and too little immune response lead to organ shutdown. First, we used ‘Watson’…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.