Carattino Lab

Research focus

NIH R01 · 2024

Role of acid-sensing ion channels in bladder sensory signaling

(PLEASE KEEP IN WORD, DO NOT PDF) The urinary bladder is a common source of visceral pain, one of the most frequent reasons why patients seek medical attention. Despite the primordial role that afferent pathways have in normal bladder sensation and nociception, we have limited understanding of the molecular events contributing to these processes. This proposal aims to understand the mechanisms by which acid-sensing ion channels (ASICs) regulate bladder afferent signaling. The proposal builds on the findings that the loss of ASIC3 in naïve mice reduces the intravesical pressure required to trigger micturition, while in the setting of chemically-induced cystitis it results in the…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.