NIH R01 · 2025
Functional relevance of C. trachomatis trp operon polymorphism
PROJECT SUMMARY The trp operon in several bacterial species is regulated at multiple levels that include transcription, translation, post-translation, and enzyme activity. The recent discovery of a distinct attenuation mechanism of C. trachomatis trp operon, which we termed “trans”-attenuation because it involved a trans-acting factor, the tryptophan- biosensing YtgR repressor, points to the significance of maintaining stringent regulation of expression of the tryptophan salvage genes. Regulation of trp operon by the TrpR repressor and attenuator is thought to be a check on the relatively high metabolic cost of tryptophan biosynthesis, with transcription only induced when tryptophan levels…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.