NIH R01 · 2025
Levothyroxine Dosing in Older Individuals
PROJECT SUMMARY Approximately 10% of US adults aged 65 years or older take levothyroxine to treat hypothyroidism. Guidance for its management has vast and important implications for the health and health care expenditures of millions of older people. Levothyroxine has a narrow therapeutic index that requires monitoring of dosing through thyroid stimulating hormone (TSH) testing. The current TSH reference range is based on the population distribution of younger people, despite evidence for a shift to higher levels with increasing age. Furthermore, observational data do not demonstrate adverse clinical consequences if people with TSH levels just above the reference range are left untreated,…
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