NIH R01 · 2025
Cardiac microtubules as regulators of diastolic function.
Abstract Diastolic heart disease (DHD) is the leading cause of death and disability worldwide. With no FDA approved therapies to improve diastolic function, the NIH has placed special emphasis on collaborative initiatives bridging basic science and clinical data to understanding the molecular mechanism of DHD. The hallmarks of diastolic heart disease are a stiffening left ventricle and an inability for the heart muscle to relax, both of which occur in DHD by mechanisms that are poorly understood. Building on recent work that the cardiac microtubule network (MTN) can both stiffens and impairs the relaxation of failing cardiomyocytes, in Aim 1 we determine the relative contribution of the MTN…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.