NIH R01 · 2024
Nuclear Pore Complexes As Scaffolds For Genome Architecture And Epigenetic Maintenance
The Nuclear Pore Complex (NPC) is a nuclear envelope embedded multi-component complex, which mediates transport of molecules between the nucleus and the cytoplasm. In addition to their classical function in transport, NPC components (Nups) have been implicated in transcriptional regulation via binding to the genome. Yet what regulatory steps of transcription are controlled by Nups and how chromatin-binding roles of Nups contribute to metazoan development is currently unclear. We identified the binding of multiple Nups to hundreds of promoters and enhancers in the Drosophila genome, and discovered a previously unreported role of the NPC in the formation of enhancer-promoter loops.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.