NIH R01 · 2024
Molecular architecture of the human knee joint and pelvis at single cell resolution
Project Summary/Abstract At the cornerstone of human bipedal locomotion are the pelvis and knee, two hind limb skeletal structures for which we know little about their respective development in humans. Indeed, these structures have complex 3-D morphologies whose initial patterns arise during the chondrogenic anlagen stage, when coordinated cellular differentiation and proliferation establish various tissue types and the spatial relationships between different structural components (e.g., between the knee’s distal femoral condyles and proximal tibial platform, or between the pelvis’ ilium, pubis, ischium, and acetabular subdomains). Yet, for developing human skeletal structures, we…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.