NIH R01 · 2024
Subchondral Bone Cavities in Osteoarthritis Pain
ABSTRACT Chronic pain is the most prominent symptom of osteoarthritis (OA) and a key reason why patients seek medical help. Persistent pain at rest profoundly affects the quality of life and daily physical activity. Pain itself is a risk factor for the development of future functional decline and increasing pain is a predictor of physical functional limitation and disability. Osteoarthritic pain is thought to emanate from small myelinated or unmyelinated fibers in one or more tissues including synovium, ligament, subchondral bone, and meniscus. In clinic, subchondral bone marrow edema-like lesions (BMLs) visualized by MRI are highly correlated with OA pain. Thus, the observation suggests…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.