NIH R01 · 2025
Development of Cerebellar-Cortical Functional Connectivity in Youth and Its Prediction of Psychosis
Abstract Cerebellum dysfunction is known to be strongly implicated in the pathogenesis of psychosis. Our past research has provided converging evidence that functional dysconnectivity in the cerebellar-cortical circuitry is a robust neural anomaly that is ubiquitously manifest across different clinical stages and brain states in psychotic patients, predictive of psychosis onset, and related to genetic risk for psychosis. Therefore, cerebellar-cortical dysconnectivity is likely to reflect a pathological trait arising from abnormal neurodevelopment, emphasizing the importance of understanding the developmental trajectories of cerebellar-cortical connectivity and their associations with…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.