NIH R01 · 2025
Investigation in the role of L-type Ca2+ channel CaV1.2 in Achilles tendinopathy
PROJECT SUMMARY The tensile-bearing Achilles tendon is highly prone to acute- or overuse-induced injuries that lead to chronic tendon degeneration and heterotopic ossification (HO) called tendinopathy. Achilles tendinopathy is often associated with pain and disability with high socio-economic costs. The current standard of care for treating Achilles tendinopathy does not result in effective long-term functional recovery, although it provides short-term pain relief. The pathogenetic mechanisms of Achilles tendinopathy are largely unknown. Identification of early mediators in tendon in response to injury and elucidation of the cellular and molecular mechanisms underlying the pathogenesis of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.