NIH R01 · 2025
Linking the molecular operations of cohesin to its physiological activity in the mammalian brain
PROJECT SUMMARY Mammalian genomes are organized into loops and topologically associated domains by the cohesin protein complex. The formation of these structures has suggested models for how DNA regulatory elements, such as enhancers and promoters, are spatially arranged to coordinate gene expression. However, testing these models and their implications in cellular function and fate has been challenging due to the lack of systems for interrogating the activity of cohesin in vivo. Using mouse olfactory sensory neurons and serotonergic neurons from the raphe nuclei, post-mitotic cells in which the role of cohesin in genome function can be uncoupled from its role in sister chromatin cohesion,…
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