NIH R01 · 2024
Contribution of a novel OPN-producing CD11c+ microglial subset to AD
Summary We have recently identified a small subset of CD11c+ microglia as the sole producer of OPN (Osteopontin; Spp1) and major disease driver in the 5XFAD mouse model of Alzheimer’s Disease (AD). Our analysis of OPN- producing CD11c+ microglia has divided Disease-Associated Microglia (DAM) that surround Aβ plaques into two opposing subsets that together regulate AD pathology. A pathogenic CD11c+OPN+ microglial subset promotes proinflammatory responses and drives AD development, and a protective CD11c+OPN− microglial subset degrades Aβ fibrils and inhibits disease pathology. We find that genetic deletion of OPN (a) inhibits microglial proinflammatory responses, (b) enhances…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.