NIH R01 · 2024
Macrophage Function in Kidney Repair
Repair of the kidney tubules after an acute insult requires the clearance of dead cells and proliferative repopulation of the tubules by those cells that survive the initial insult. Our data obtained by tracking individual tubules using high resolution multiphoton Z-stack images on days 1 and 3 after ischemia-reperfusion injury confirms that the S3 segment of the proximal tubule is the site of most tubular cell loss and intraluminal cast formation, and that epithelial proliferation and cast clearance dominate the histologic findings in the outer stripe of the renal medulla from days 2-5 after injury. During this exact time, macrophages (termed mononuclear phagocytes (MNPs) for uniformity)…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.