NIH R01 · 2024
PFAS induced alterations in reward processing
Per- and polyfluoroalkyl substances (PFAS) are widespread environmental contaminants that have been investigated as developmental toxicants, with little information on long-term neurotoxicity and clinical outcomes. Our preliminary data suggest that PFAS may produce neurotransmission changes relevant to psychiatric disorders involving abnormal reward processing, specifically anhedonia. We will test the hypothesis that: early life PFAS exposure will produce alterations in reward processing mediated through specific neurotransmission targets. Importantly, the hypothesis will be tested in animal models and humans, utilizing innovative translational approaches. We will test our hypothesis…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.