NIH R01 · 2024
Mitochondria mediated intercellular metabolic coupling in bone marrow regeneration
(PLEASE KEEP IN WORD, DO NOT PDF) Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Hematopoietic stem cell (HSC) transplantation (HSCT) after conditioning is widely used in the clinic to treat pathological mutations in the lympho-hematopoietic system. The mechanisms on how the bone marrow (BM) microenvironment (ME) and transplanted HSC interact remains a mystery in biology. Understanding the underpinning mechanisms controlling mesenchymal BM-ME and HSC is arguably a major area of interest to optimize HSCT and generate optimal HSCT protocols that result in complete hematopoietic chimerism in the host with…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.