NIH R01 · 2025
A Dynamic Diversity of Dopamine Neurons
We aim to understand the biophysical mechanisms that enable the distinct intrinsic dynamics of projection- defined dopamine (DA) neuron subpopulations by a combination of modeling and in vivo/in vitro experimental strategies. We focus on how intrinsic dynamics differ between defined DA subpopulations, and how those differences shape the integration of synaptic input within the circuit, including newly identified modes of burst generation in DA neurons in vivo: plateau bursting and rebound bursting. We contrast a compressed dynamic firing range DA population (DACR) with an extended dynamic range (DAER) based upon the maximum frequency exhibited in response to depolarization, thereby probing…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.