NIH R01 · 2024
Cytoskeletal compartmentalization of apoptotic signaling
PROJECT SUMMARY The actin cytoskeleton impacts virtually every function of a human cell. Sophisticated regulatory mechanisms ensure that actin polymerizes when and where it is needed, and the assembly of actin filaments de novo is driven by proteins called nucleation factors. While the cytoskeleton is known to provide structure and generate forces in cellular processes that maintain viability, how it affects programmed cell death in response to stress is not well understood. To address this question, we are investigating the mechanisms by which actin nucleation factors from the mammalian Wiskott-Aldrich Syndrome Protein (WASP) family control apoptosis following DNA damage. Our recent…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.