NIH R01 · 2024
Profiling Translation in Nociceptor Plasticity
Project Summary/Abstract Chronic pain is a pervasive and devastating condition. Translational control is a dominant theme in synaptic plasticity and plays a key role in pain plasticity, in particular the plasticity of peripheral nociceptors. Messenger RNA (mRNA) is subject to dynamic regulation by signaling pathways implicated in plasticity such as the integrated stress response (ISR) and mTOR. Yet, the identity of the mRNAs in nociceptors subjected to regulated translation during plasticity events is virtually unknown. Here, we use an exciting new genomics method termed ribosome profiling to gain genome-wide insight into translation control events in DRG neurons. Our preliminary studies…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.