Campbell Lab

Research focus

NIH R01 · 2024

Human platelet PAR4: novel activation, interindividual variation, and neutrophil interactions in vivo and in vitro

This application is a new submission extending prior research funded by HL102482, initially funded in 2009 to identify the genetic basis for inter-individual variation in platelet function that contributes to ischemic occlusion of arteries. We generated a human reference platelet transcriptome, developed a public, user-friendly interactive web tool to query platelet function and RNA-protein associations, and discovered platelet aggregation through the protease activated receptor-4 (PAR4) thrombin receptor was greater in blacks than whites. We showed this difference was due to a PAR4 Ala120Thr substitution with racially divergent allele frequencies (Thr120: .63 blacks; .19 whites). The…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.