NIH R01 · 2025
Alpha- to Beta-Cell Communication in Health and Disease
Summary of Work Glucagon is canonically viewed as an essential counterregulatory hormone that prevents hypoglycemia by driving endogenous glucose production (EGP) in the liver. We and others have revealed additional roles for glucagon that emphasize a much more complex control of metabolism beyond hypoglycemia. On such role is our studies revealing the potent insulinotropic actions of glucagon in β-cells, which we have shown to be essential for postprandial glucose control. Glucagon production in α-cells comes from the specific processing of a proglucagon peptide by prohormone convertase 2 (PC2). Emerging literature has proposed that α-cells can differentially process the proglucagon…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.