NIH R01 · 2025
PATHOGENESIS AND IN VIVO SUPPRESSION OF THIN FILAMENT-BASED CARDIOMYOPATHIES
Project Summary The thin filament is a multi-subunit regulatory machine. Proper regulation of cardiac contraction requires communication among, and controlled movement of, individual thin filament proteins. The goal of this application is to understand how post-translational modifications (PTMs) and human cardiomyopathy mutations, located at conserved interfaces between thin filament subunits, affect protein-protein associations, modulate muscle function, and/or lead to disease. Drosophila melanogaster benefits from robust experimental tools that permit efficient, yet comprehensive, scrutiny of the most proximal consequences of thin filament perturbations. This animal model will continue to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.