NIH R01 · 2024
The role of antiretroviral therapy in susceptibility to oral human papillomavirus (HPV) infection
ABSTRACT People living with human immunodeficiency virus (HIV) infection (PLWH) remain at increased risk of developing head and neck squamous cell cancer (HNSCC) due to oncogenic human papillomavirus (HPV) infection, despite adequate management of HIV with effective antiretroviral therapy (ART). Clinical observations have indicated increased risk of oral HPV infection and pathology in PLWH after they begin taking ART and concurrent with a significant drop in HIV viral burden. Prior in vitro studies using 3D experimental tissue models that mimic stratified squamous epithelium have suggested that exposure of the tissue to ART agents disrupts the structural integrity of the tissue and enhances…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.