NIH R01 · 2024
Inflammation, Lipid Metabolism and Senescence
ABSTRACT Aging is a complex process brought about by a combination of genetic, hormonal and metabolic determinants. Of the factors defined as mechanistically linked to fundamental processes of aging, often referred to as the “pillars of aging”, inflammation and cellular senescence of adipose tissue take center stage. The focus of this application is the interface between immune cells, adipocytes and cellular senescence with an emphasis on the role(s) that lipids play in orchestrating B-cell biology, adipocyte oxidative stress and senescence. Recently published work from Camell and colleagues describes the age-dependent decrease in catecholamine signaling that occurs in adipose tissue due to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.