NIH R01 · 2024
Molecular regulation of native hematopoiesis
SUMMARY Decades of work have established a paradigm for hematopoietic regeneration and maintenance based on the activity of multipotent hematopoietic stem cells (HSCs) at its apex. Our understanding of the fundamental properties of HSCs and progenitor populations has been historically based on notions derived from transplantation assays. Data over the last few years, however, have challenged the most fundamental aspects of models based on these studies, and have raised biological questions that are of direct clinical relevance in the hematology field. Additionally, it is now clear that intrinsic heterogeneity exists among seemingly pure populations of HSCs and downstream progenitors. How…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.