NIH R01 · 2025
Regulation of CSE-Derived Hydrogen Sulfide in the Heart
Project Summary Hydrogen sulfide (H2S) is an endogenously produced signaling molecule that impacts protein function by modifying cysteine residues through the formation of a persulfide bond by a process termed sulfhydration (persulfidation). It is produced enzymatically by three enzymes in the cysteine biosynthesis pathway: cystathionine-γ-lyase (CSE), cystathionine-β-synthase (CBS), and 3-mercaptopyruvate sulfutransferase (3- MST). Numerous studies have reported a protective role for H2S in experimental models of acute myocardial ischemia-reperfusion injury and heart failure. While these studies and others have established a cytoprotective role for H2S, there are still unresolved questions…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.