NIH R01 · 2024
ABSTRACT Plasticity mechanisms endow the brain with immense capacity to adapt to a wide range of experience and exposures. Protein synthesis, including locally at synapses, is a requirement for many forms of synaptic plasticity. The Integrated Stress Response, ISR, is a highly conserved biochemical pathway that regulates protein synthesis. The ISR markedly shifts which proteins are made by phosphorylating the initiation factor, eIF2alpha. The ISR was named for its effects body-wide - in which it provides a cell stress response mechanism. However, in the brain, the ISR has also been found to be a potent modifier of synaptic plasticity, learning and memory. At a high level of summary, ISR…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.