Cairns Lab

Research focus

NIH R01 · 2024

Molecular, Epigenetic and Genomic Approaches to Understand Mechanisms of Aging in the Human Testis

PROJECT SUMMARY ABSTRACT Due partly to socio-economic reasons, there is a general trend of increased parental age in the industrialized countries. Advanced parental age is known to be associated with several risk factors including decreased genome integrity, impaired organ maintenance, increased mutations (which may cause testicular cancer), altered epigenome in the germline, and reduction in fertility. Importantly, these germline alterations can be transmitted to the offspring, resulting in higher risks for several diseases/syndromes (e.g. Achondroplasia, Apert, Noonan and Costello) in their children. However, the detailed molecular mechanism underlying human testis aging is highly…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.