NIH R01 · 2024
Project Summary/Abstract: Major depressive disorder (MDD) is a common but serious mental illness that negatively affects emotion, cognition, physical activity, and increases mortality. In general, the manifestation of depression is thought to be due to the imbalance of neurotransmitters in the brain. These neurotransmitters include glutamate, GABA, and especially a class of monoamines, such as serotonin, dopamine, and norepinephrine. Many recent studies have demonstrated the importance of dopamine homeostasis and dynamics on reward and motivation especially after exposure to chronic stress. Our previous studies have identified a novel astrocyte-dependent modulatory mechanism for the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.