NIH R01 · 2025
The Role of Abnormal Inter-Organelle Communication in the Pathogenesis of Tauopathy
PROJECT SUMMARY Hyperphosphorylation and aggregation of microtubule-associated tau is a pathological hallmark of tauopathies, which constitutes one of the two defining features of Alzheimer’s disease (AD). In AD, tau pathology correlates with neuronal death and cognitive dysfunction better than amyloid plaques. Thus, understanding the pathogenic mechanisms underlying tau buildup and toxicity is of great importance in developing tau-targeting therapy for treating AD and other tauopathy diseases. Pathologically phosphorylated tau (p-tau) is known to be degraded within lysosomes after sequestration within autophagosomes/autophagic vacuoles (AVs). Earlier studies of tauopathy patient brains…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.