NIH R01 · 2025
Noninvasive High-Resolution Mapping of HCC Tumor Biology Predictive of Malignancy
PROJECT ABSTRACT: Hepatocellular carcinoma (HCC) is an aggressive malignancy representing the 7th most common cancer globally and the 4th most common cause of cancer death worldwide. Although magnetic resonance imaging (MRI) represents a common HCC diagnostic and prognostic tool, MRI fails to provide insights into HCC risk stratification, and does not allow for rational therapeutic allocation. Chemical exchange saturation transfer (CEST) molecular MRI, on the other hand, permits noninvasive measurement of tumor metabolism predictive of malignancy. Integration of CEST MRI into clinical HCC management has the potential to radically alter clinical practice paradigms through: (1) identification…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.