NIH R01 · 2024
Targeting Wnt signaling pathway
Protein-protein interactions (PPIs) are increasingly important targets for bioorganic and medicinal chemistry, given the critical role of myriad protein complexes in vital biological processes including signal transduction, cell growth and proliferation, etc. Due to enhanced stability and functional diversity, helical peptidomimetics have emerged as a promising strategy for targeting PPIs, however their application is still limited as they generally do not mimic α-helices well owing to their difference in the three-dimensional helical structures. For instance, BCL9/β-catenin and TCF/β-catenin PPIs involved in Wnt signaling pathway play an important role in embryonic development and tissue…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.