NIH R01 · 2025
Characterization of ApoE4 Induced Phospholipid Dysregulation in AD Pathogenesis
PROJECT SUMMARY APOE4 is the strongest genetic risk factor for sporadic AD with Ab-dependent and Ab-independent effects on disease pathogenesis. However, the molecular mechanisms underlying the pathogenic nature of APOE4 are not fully elucidated. In previous funding period, we have demonstrated that APOE4-induced phosphoinositol biphosphate (PIP2) dyshomeostasis through the increased expression of a PIP2-degrading enzyme, synaptojanin 1 (synj1). In parallel, a non-biased multiscale network analysis of human dataset from the AMP-AD consortium identifies synj1 as a key driver in both male and female AD subnetworks. Synj1 reduction has been found to provide several beneficial effects such as…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.