NIH R01 · 2025
Scalable high-plex pipeline for whole-brain proteomics profiling
Abstract Knowing the molecular signature of distinct brain cell types in the human brain is relevant for basic neuroscience research and understanding neurological disease. While past and ongoing large-scale scRNAseq and spatial transcriptomics efforts have provided a comprehensive mRNA expression atlas, there lacks a similar proteomics atlas due to the limited profiling throughput of current methods. Additionally, studies have shown expression discrepancy between the transcription and translation levels, especially during development. Therefore, mapping proteomes, not just transcriptomes, is crucial to providing a comprehensive understanding of the cell-type molecular signatures. Current…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.