NIH R01 · 2025
PROJECT SUMMARY Cognitive abilities have a profound impact on life outcomes. As such, there has been much scientific interest in identifying genes that are critical for regulating cognitive phenotypes. The miR-132 microRNA is among the few studied microRNAs that impacts learning and memory in rodents, is dysregulated in multiple human disorders typified by cognitive impairment, and regulates synaptic structure and function. Human genome wide association studies (GWAS) have identified numerous genes of potential relevance to general cognitive function, yet a challenge is identifying which genes, among the many, are likely to have direct effects on learning and memory. Genes that are targets…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.