NIH R01 · 2024
Molecular Mechanisms of Membrane Transport
Active membrane transport is central to many cell processes, including the acquisition of nutrients, the establishment of ion-gradients, the regulation of osmotic balance, ATP synthesis, and apoptosis. The proposed work will address key questions regarding the mechanisms of nutrient uptake in Escherichia coli, and it will address questions regarding the structure and organization of these proteins in the bacterial outer-membrane. In E. coli, a range of nutrients are transported by specific outer-membrane proteins that derive energy by coupling to the inner- membrane protein TonB. These TonB-dependent transporters include BtuB, which is responsible for vitamin B12 transport, and FhuA, FecA…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.