NIH R01 · 2024
Defining and exploiting the plasticity transcriptome to repair the damaged spinal cord
SUMMARY A century of research has shown that the adult central nervous system is incapable of self-repair after injury or disease. Indeed, adults with traumatic spinal cord injuries maintain chronic functional deficits that impact all aspects of their lives. However, increasing evidence suggests that the adult CNS retains some ability to initiate a growth program and functionally re-organize in response to activity, experience and mild trauma and particularly after intensive rehabilitative therapy. In this proposal we have used in vivo viral tracing in combination with FACS and single cell RNA sequencing to develop a comprehensive anatomical and molecular atlas of the adult corticospinal…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.