NIH R01 · 2025
Characterization of a commensal enteric virus
SUMMARY Crosstalk between immune cells and the epithelium protects the intestinal barrier from infectious and non- infectious threats. Elucidating the signals that mediate this cellular crosstalk is necessary to improve our understanding of diseases associated with barrier dysfunction, such as Crohn's disease (CD), a major type of inflammatory bowel diseases (IBD). We previously established a model to investigate how a commensal and otherwise beneficial virus induces immune-mediated damage in a genetically susceptibility host. Infection of Atg16L1 mutant mice with murine norovirus (MNV) inhibits the function and viability of Paneth cells, antimicrobial epithelial cells in the gut. Tissue…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.