NIH R01 · 2025
5/5 Biomarkers to Enhance Early Schizophrenia Treatment (BEEST)
PROJECT SUMMARY The onset of a first episode of psychosis (FEP) in late adolescence or early adulthood often leads to lifelong disability. Timing and precision of treatment are of the essence during this critical developmental period. Unfortunately, FEP patients who do not respond to a conventional first-line antipsychotic (FL-AP) are often delayed in transitioning to clozapine (CLZ) - or never switch at all - despite the clear superiority of CLZ to FL- APs in treatment resistant individuals. However, CLZ treatment involves risks of severe side effects, including agranulocytosis and weight gain. Currently, clinicians and patients currently have no objective, clinically validated tools to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.