NIH R01 · 2025
Aldosterone and the menopausal transition's increase in blood pressure and cardiovascular risk
There is more female hypertension-related mortality than male. Although women’s blood pressure is lower than men’s in younger life, after menopause the reverse is true. A decrease in estrogen plays a role in women’s midlife increase in blood pressure. However, factors that modify the extent of this increase in individuals are not known. The renin-angiotensin-aldosterone system (RAAS) is crucial to blood pressure regulation, and it is also the target of many antihypertensive medications. These different medications vary in their effects, depending on where in the RAAS they act. Angiotensin-converting enzyme inhibitors (ACEis) and angiotensin-receptor blockers (ARBs) do not reliably prevent…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.