NIH R01 · 2024
Sex differences in modulating HIV/SIV reservoirs in the context of opioids
Abstract Due to the widespread use of antiretroviral therapy, HIV replication is effectively controlled in infected individuals. However, viral reservoirs form early post-infection, posing a persistent challenge to complete virus eradication. It has been suggested that sex differences may influence the establishment of HIV reservoirs, with variations between women and men attributed to socio-economic and biological factors, a phenomenon further compounded by opioid use. Established knowledge indicates that women are more susceptible to HIV acquisition than men due to robust estrogen receptor signaling. Despite this, women tend to exhibit lower viral loads and more robust antiviral responses…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.