NIH R01 · 2025
Molecular Mechanisms of Sugar Sensing by Insect Gustatory Receptors
PROJECT SUMMARY Animals desire sugars for their energy potential and for the pleasurable sensation of tasting sweetness. Despite the importance of sugar receptors in influencing nutrient sensing, metabolic responses, and taste perception, few studies have been performed to identify the molecular mechanisms underlying sugar detection and recognition. The proposed project will address this gap by integrating structural and functional studies to offer a unique perspective on the biophysical basis for sweet taste. In the first two Aims, we will focus on a single exemplary GR, Gr9 from the silk moth Bombyx mori, and couple structural methods with mutagenesis and functional assays to understand…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.