NIH R01 · 2024
Assessing the mechanisms directing cell fate in the dorsal spinal cord
Project Summary The somatosensory system permits us to perceive and react to the environment through modalities that include touch, nociception, thermosensation and proprioception. Somatosensory information is received peripherally and then relayed centrally by different populations of dorsal interneurons (dIs; dI1-dI6) in the spinal cord. Our research objectives are to understand the mechanisms that establish dIs during development and then apply these principles towards designing differentiation protocols to direct the formation of specific populations of dIs from pluripotent stem cells. These cells have the potential to repair damaged sensory circuits and act as substrates for drug…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.