NIH R01 · 2025
Preserving bone marrow niche integrity and function to rejuvenate aged hematopoietic stem cells
PROJECT SUMMARY The aging process is associated with an increased risk of failure of therapeutic strategies to treat hematopoietic diseases, which often rely on myelosuppression and transplantation of hematopoietic stem cells (HSCs). There is a substantial need for the development of preventative and therapeutic options to delay the aging process, to rejuvenate tissues/organs, and to enhance regeneration and repair. However, the ability to truly rejuvenate aged HSCs or their supportive niches has eluded scientists. To date, published rejuvenation studies have shown marginal improvements in a few aspects of aged HSC function and have made exaggerated claims of `HSC rejuvenation' without…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.