NIH R01 · 2024
Novel Lymphocyte Chemoattractant Receptor and Ligand
PROJECT SUMMARY/ABSTRACT The immune system at mucosal sites has evolved to mediate rapid immunity to invading pathogens, while limiting over-reactive responses that drive chronic inflammation. Mechanisms of lymphocyte trafficking are essential for the function and systemic integration of the immune system, and in particular for targeting immune responses to specific mucosal and epithelial organs and tissues in the body. Despite identification of trafficking receptors for the small intestines, colon, and skin, we have limited knowledge of mechanisms of lymphocyte recruitment to the lung and to most non-intestinal mucosal sites. Defining mechanisms controlling organotypic lymphocyte homing to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.