NIH R01 · 2025
PROJECT SUMMARY/ABSTRACT Down syndrome (DS) is a developmental genetic condition caused by trisomy of human chromosome 211-6. DS occurs in approximately 1 in 600-1000 live births and affects more than 300,000 individuals in the USA. Neuropathological and clinical features of Alzheimer’s disease (AD) present early in life through the seventh decade in a predictable sequence of events, and include amyloid plaques, neurofibrillary tangles, nerve growth factor (NGF) dysmetabolism and cholinergic basal forebrain degeneration, CNS inflammation, and cognitive decline1-10. DS is an outstanding natural genetic model for the study of AD pathophysiology, AD biomarkers research and to conduct…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.