NIH R01 · 2024
Molecular Profiling and Biomarkers of Memory Phenotypes in Temporal Lobe Epilepsy
PROJECT SUMMARY Temporal lobe epilepsy (TLE) is a leading cause of seizure disorders in adults and is associated with high risk of memory deficits that can negatively impact day-to-day functioning and quality of life. Memory deficits are most prevalent in those with pharmacoresistant mesial TLE and hippocampal sclerosis (MTLE-HS). However, a large subset of patients with MTLE-HS paradoxically have intact memory performance, even with histopathological evidence of marked hippocampal cell loss. Despite the high prevalence of memory impairment in patients with TLE, very little is known about the underlying pathophysiological etiologies of such memory dysfunction and there are no predictive…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.