NIH R01 · 2025
Cholesterol Regulation Through Retriever-Dependent LDL Receptor Recycling
PROJECT SUMMARY Elevated plasma LDL cholesterol is a potent risk factor for atherosclerosis and cardiovascular complications. LDL is cleared from circulation by LDL receptors (LDLR). Importantly, the balance between internalization, recycling, and intracellular degradation of LDLR is critical in determining surface expression of LDLR, LDL clearance, and plasma LDL concentrations. A pivotal regulator of endosomal recycling of LDLR is the trimeric protein complex known as Retriever. Comprised of VPS35L, VPS26C, and VPS29, Retriever is essential for identifying cargo proteins in the endosomal compartment to initiate their recycling to the plasma membrane (PM). Over the past year, our multi-PI…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.