NIH R01 · 2024
Enhancing T and B cell responses to Plasmodium infection and vaccination via IL-15
PROJECT SUMMARY/ABSTRACT Malaria, which results from infection with Plasmodium parasites, is a significant global health problem with nearly 250 million clinical cases and over 600,000 deaths annually worldwide. With growing anti-malarial drug and insecticide resistance, new therapeutic strategies and highly effective vaccines are urgently needed. Protection against symptomatic disease develops after years of repeated exposures to Plasmodium parasites. However, there is no definitive evidence of long-lived, sterilizing immunity in humans following repeated exposure to Plasmodium parasites, and clinical immunity to malaria rapidly wanes in the absence of re- infection. Similarly, the limited…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.