NIH R01 · 2024
Microglial Activation during Photoreceptor Degeneration
Project Summary Retinal degeneration is a leading cause of blindness worldwide. All current treatments for retinal degeneration, including experimental therapeutics like stem cell or gene replacement therapy, are thought to be most effective when degeneration is caught in its earliest stages. Unfortunately, the earliest detectable symptom of degeneration is often visual impairment, which is only detectable after a large number of retinal cells have died and disappeared. The ability to discern the first signs of cell stress, prior to apoptosis and degeneration, could significantly improve the likelihood of delaying or preventing vision loss. One common early indication of degeneration is…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.